This page is for businesses that have lost control of their Microsoft 365. Nobody can sign in as an administrator, or the only people who can are a former employee or a provider you can no longer reach. If you can still sign in as an administrator and want that checked, start with admin account ownership instead.
The way back depends on the kind of tenant. A cooperative handover is quickest. If Microsoft 365 was never properly set up and only exists because staff signed up with their work email, it is an unmanaged tenant, and Microsoft's admin takeover lets the business take control by proving it owns the domain. If the tenant was set up properly and has an administrator nobody can reach, that takeover does not apply: the route is another administrator in the tenant or a request to Microsoft support, where the business proves it owns the account and Microsoft decides. If a provider still holds admin access and refuses to hand it over, that can become a dispute to settle first. Owning the domain helps in every case, but it is not a master key.
The usual situations are undramatic. A contractor set it up years ago on their own account. An employee who has left is the only global admin. A provider relationship ended badly. In each case the business has been paying for something it cannot administer.
Businesses in Dallas-Fort Worth can read how we work locally on the DFW Microsoft 365 page.